What are the challenges of conducting pragmatic trials (PCTs)?

Iris Goetz

Global Health Outcomes

Eli Lilly, UK

Get REAL PRoject 
IMI Work Package WP3 

Focus on randomisation

RCT in real world !

Aim

consequences of design

consequences of design choice

key activities

ensure feasibility while keeping validity

literature review

practical solutions

toolbox

stakeholders interviews

Definition of pragmatic trials -various- 

mainly  trials comparing different health interventions -effectiveness

Comparing RCT (randomised clinical trials) with PCT (pragmatic clinical trials)

Which design criteria important in designing a PCT?

Comparison of Treatments Arms -questions to be answered

Baseline-do we need wash-out period?

link hospital data with the GP data